科研星球

「电子书」垃圾 DNA: 基因组暗物质之旅 Junk DNA: A Journey Through the Dark Matter of the Genome PDF

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在确定了DNA的结构后的几十年里,科学家们只关注基因,即基因组中含有生产蛋白质的代码的区域。构成人类基因组98%的其他区域被认为是 "垃圾",没有任何作用的序列。然而,最近研究人员发现了这些垃圾DNA的变异和调整,它们是一些难以治愈的疾病的基础。这一知识导致了创新的研究和治疗方法,可能最终控制这些疾病。


垃圾DNA可以在控制基因表达方面发挥重要的、意想不到的作用,从微调单个基因到关闭整个染色体。它的功能迫使科学家们重新审视 "基因 "一词的含义,并引发了一场关于这种基因组 "无稽之谈 "是否是人类生物复杂性来源的激烈斗争。Nessa Carey利用她在欧洲和北美领先的研究人员的经验,对垃圾DNA及其在遗传病、病毒感染、哺乳动物的性别决定、疾病治疗和进化等各种现象中的关键参与进行了清晰而令人信服的介绍。我们现在才揭开垃圾DNA的秘密,而凯里的书是浏览这个快速增长且争议激烈的领域的密码和争议的不可或缺的资源。


For decades after identifying the structure of DNA, scientists focused only on genes, the regions of the genome that contain codes for the production of proteins. Other regions that make up 98% of the human genome were dismissed as "junk," sequences that serve no purpose. Yet recently researchers have discovered variations and modulations in this junk DNA that underwrite a number of intractable diseases. This knowledge has led to innovative research and treatment approaches that may finally control these conditions.


Junk DNA can play vital and unanticipated roles in the control of gene expression, from fine-tuning individual genes to switching off entire chromosomes. Its function has forced scientists to revisit the very meaning of the word "gene" and has engendered a bitter battle over whether or not this genomic "nonsense" is the source of human biological complexity. Drawing on her experience with leading investigators in Europe and North America, Nessa Carey provides a clear and compelling introduction to junk DNA and its critical involvement in phenomena as diverse as genetic diseases, viral infections, sex determination in mammals, disease treatments, and evolution. We are only now unlocking the secrets of junk DNA, and Carey's book is an indispensable resource for navigating the codes and controversies of this fast-growing and hotly disputed field.

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