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「电子书」Clinical Trials: A Methodologic Perspective Second Edition(Wiley Series in Probability and Statistics) 临床试验: 一个方法论的观点第二版(怀利系列的概率与统计) PDF

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这本书非常独特。清楚地介绍了基本的统计学概念,但只是那些在临床试验中很重要的概念。作者介绍了临床试验的所有问题,包括具有一定历史意义的伦理问题。清楚地介绍了随机化和统计设计的原则。它提供了关于贝叶斯技术和元分析、交叉设计和分组顺序方法(中期分析)的讨论。对于像我这样从事临床研究的统计学家来说,这是一个宝贵的参考资料。


This book is very unique. Basic statistical concepts are clearly presented but only those concepts that are important in clinical trials. The author presents all the issues with clinical trials including ethical issues with some historical perspective. Principles of randomization and statistical design are clearly presented. It offers discussion of Bayesian techniques and meta-analyses, cross-over designs and group sequential methods (interim analyses). For statisticians doing clinical research like myself, this is a valuable reference source. 

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