随着更多物种的基因组被测序，这些数据的计算分析已变得越来越重要。这本广受赞誉的教科书的第二版完全更新，对分析DNA、RNA和蛋白质数据以及基因组所需的计算方法进行了全面而严谨的审查。该书经过重写，使其更容易被更多人接受，包括高级本科生和研究生。新的特点包括章节指南和解释性信息板以及术语表。第二版的新章节涵盖了序列排列的统计分析，生物信息学的计算机编程，以及数据管理和挖掘。各章结尾处以实践为导向的问题提高了该书作为教学资源的价值。本书也可作为分子生物学、制药和基因组实验室的专业人员的基本参考资料。

As more species' genomes are sequenced, computational analysis of these data has become increasingly important. The second, entirely updated edition of this widely praised textbook provides a comprehensive and critical examination of the computational methods needed for analyzing DNA, RNA, and protein data, as well as genomes. The book has been rewritten to make it more accessible to a wider audience, including advanced undergraduate and graduate students. New features include chapter guides and explanatory information panels and glossary terms. New chapters in this second edition cover statistical analysis of sequence alignments, computer programming for bioinformatics, and data management and mining. Practically oriented problems at the ends of chapters enhance the value of the book as a teaching resource. The book also serves as an essential reference for professionals in molecular biology, pharmaceutical, and genome laboratories.