本卷研究了线粒体在不同类型细胞死亡中的作用，包括细胞凋亡和坏死。讨论的主题包括线粒体外膜通透性（MOMP）和通透性转换孔；核心过程如钙处理、裂变和融合、活性氧的产生以及线粒体DNA保真度和蛋白质折叠稳态的维持；线粒体与其他细胞成分之间的逆行信号传递，包括线粒体在抗病毒免疫中的重要作用。专家撰写的章节从多学科的国际视角出发，使教材的内容细致全面。线粒体与细胞死亡》是《生物学与疾病中的细胞死亡》系列丛书的一部分，对于神经科学、肿瘤学、胃肠病学和肝病学等领域的研究生、研究人员和临床医生，以及对线粒体和细胞生物学研究感兴趣的人来说，都是非常宝贵的读物。

This volume examines the role of mitochondria in different types of cell death, including apoptotic and necrotic cell deaths. Topics discussed include mitochondrial outer membrane permeabilization (MOMP) and the permeability transition pore; core processes such as calcium handling, fission and fusion, reactive oxygen species generation, and maintenance of mitochondrial DNA fidelity and protein folding homeostasis; and retrograde signaling between mitochondria and other cellular components, including the important role of mitochondria in antiviral immunity. The expertly authored chapters are drawn from multidisciplinary international perspectives, lending a nuanced and comprehensive approach to the material. Mitochondria and Cell Death, part of the Cell Death in Biology and Diseases series, is invaluable reading for graduate students, researchers, and clinicians in the fields of neuroscience, oncology, gastroenterology, and hepatology, as well as those interested in the study of mitochondria and cell biology.