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「电子书」Cell Death Signaling in Cancer Biology and Treatment 癌症生物学和治疗中的细胞死亡信号传导 PDF

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癌症治疗的一个关键目标是实现对肿瘤细胞的选择性和高效杀伤。细胞死亡信号在癌症生物学和治疗中的作用》旨在描述通过靶向调控癌细胞死亡的机制和途径实现这一目标的最先进方法和未来机会。在本书中,将描述癌细胞特征的细胞死亡信号传导的分子缺陷,包括由于癌蛋白的过度表达/过度激活导致的细胞死亡失调,以及肿瘤抑制蛋白的丧失。将讨论靶向microRNAs的潜力。多个章节将描述目前用于靶向表观遗传修饰、DNA修复途径和蛋白伴侣的临床前和临床方法,作为引发肿瘤细胞死亡的手段。最后,将回顾针对细胞死亡信号通路和机制的特定成分的新型药物和方法的开发和应用。


A key goal in the treatment of cancer is to achieve selective and efficient killing of tumor cells. The aim of Cell Death Signaling in Cancer Biology and Treatment is to describe state-of-the-art approaches and future opportunities for achieving this goal by targeting mechanisms and pathways that regulate cancer cell death. In this book, molecular defects in cell death signaling that characterize cancer cells, including dysregulation of cell death due to overexpression/hyperactivation of oncoproteins, as well as the loss of tumor suppressor proteins will be described. The potential for targeting microRNAs will be discussed. Multiple chapters will describe preclinical and clinical approaches that are currently being used to target epigenetic modifications, DNA repair pathways, and protein chaperones, as a means of provoking tumor cell death. Finally, the development and application of novel agents and approaches for targeting specific components of cell death signaling pathways and machinery will be reviewed.

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