科研星球

「电子书」Translation and Its Regulation in Cancer Biology and Medicine 肿瘤生物学和医学中的翻译及其调控 PDF

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本书首次全面汇集和分析了蛋白质生物合成途径的基本机制--翻译在癌症生物学中的作用的大量资料。该书系统地探讨了翻译机制及其调控(包括细胞信号转导)在人类癌症的发生、维持和发展中的功能。本书所介绍的工作揭示了这一庞大而令人兴奋的遗传、生化和分子科学分支在癌症医学和药物开发中的巨大潜力和应用。


由该领域专家贡献的章节将读者带入一个旅程,从剖析翻译机制及其在规范和癌症中的调控开始。后面的章节描述了翻译在特定癌症类型中所扮演的病因学和致病作用。本书讨论了翻译机制及其在癌症中控制的诊断、预后和治疗意义的各个方面。读者将发现翻译过程及其调节机制在生理学和癌症生物学中的重要性。


本书所收录的章节和大量插图由来自加拿大、美国、英国、意大利、法国、比利时、西班牙、德国和澳大利亚等国著名学术和临床机构的专家科学家和临床医生撰写。


本书传递的信息和知识,可能会引起广大学生和学者的兴趣,从基础科学家到临床医生和药物研发人员,都在寻求更好地了解癌症生物学和癌症医学中的蛋白质合成及其畸变。


This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosynthesis pathway, translation, in cancer biology. It systematically explores the function of the translation machinery and its regulation, including cell signaling, in the development, maintenance and progression of human cancer. The work presented here unveils the tremendous potential and applications of this vast and exciting branch of genetic, biochemical and molecular science in cancer medicine and drug development.


Chapters contributed by experts in the field take the reader on a journey that starts with a dissection of the translation machinery and its regulation in norm and cancer. Later chapters characterize etiological and pathogenetic roles that translation plays in specific cancer types. Various aspects of diagnostic, prognostic and therapeutic significance of the translation machinery and its control in cancer are discussed. Readers will discover the importance of the process of translation and its regulatory mechanisms in physiology and cancer biology.


The chapters and the numerous illustrations included here were contributed by expert scientists and clinicians from renowned academic and clinical establishments in Canada, the United States of America, the United Kingdom, Italy, France, Belgium, Spain, Germany and Australia.


The book conveys information and knowledge that may interest a broad range of students and scholars ranging from basic scientists to clinicians and drug developers seeking to better understand the protein synthesis and its aberrations in cancer biology and cancer medicine.


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