这是第一本关于人类/动物对RNA病毒感染的基因反应的综合性书籍，包括流行的、新出现的和再出现的RNA病毒，如HIV、SARS-CoV、西尼罗病毒、流感病毒等。全球著名病毒学家从以下几个方面对人类基因反应进行了评述：利用cDNA芯片和蛋白质组学等前沿技术检测到的转录和翻译水平的基因表达谱的改变；宿主对病毒在靶器官中复制的先天性和适应性免疫反应；细胞生存、凋亡和自噬体途径中病毒激活的信号转导途径；以及，小干扰RNA/microRNA介导的基因沉默途径，这是最近表征的宿主对病毒感染的新防御机制。 本书分为29个高度易懂且图文并茂的章节，探讨了RNA病毒感染和宿主与病毒相互作用的分子机制的最新知识。本书全面汇编了大多数人/动物RNA病毒在宿主细胞中的基因表达谱和信号转导途径的改变，为病毒发病机制的基础和临床研究开辟了新的方向，也为研究人员在一些传染病的诊断检测和抗病毒疗法的开发中选择基因靶点提供了有价值的生物标志物。

This is the first comprehensive book on human/animal gene responses to RNA viral infections, including prevalent, emerging and re-emerging RNA viruses such as HIV, SARS-CoV, West Nile virus, influenza virus and many others. Human gene responses are reviewed by leading virologists worldwide in the following aspects: the altered gene expression profiles at the transcriptional and translational levels detected with cutting-edge technologies such as cDNA microarray and proteomics; host innate and adapted immune responses to viral replication in target organs; virus-activated signal transduction pathways in cell survival, apoptosis and autophagosomal pathways; and, the small interfering RNA/microRNA-mediated gene silencing pathway, a recently characterized new host defense mechanism against viral infection.Organized into 29 highly accessible and well-illustrated chapters, this volume explores state-of-the-art knowledge of the molecular mechanisms of RNA virus infection and host-virus interactions. This comprehensive compilation of the altered gene expression profiles and signal transduction pathways in host cells in response to the majority of human/animal RNA viruses opens new directions for basic and clinical research on viral pathogenesis, and also provides valuable biomarkers for researchers to select gene targets in the development of diagnostic tests and antiviral therapeutics for a number of infectious diseases.