受到学生和教师的高度评价，《药理学原理。药理学原理：药物治疗的病理生理学基础》第4版为当代药理学和药物开发提供了一种基于机制和系统的综合方法。简单易懂的形式帮助一、二年级学生快速有效地掌握具有挑战性的概念。每一节都介绍了生理或生化系统的药理学，然后是该系统某一方面的药理学；一个临床小故事；系统的生物化学、生理学和病理生理学的讨论；以及通过与特定分子和细胞靶点相互作用激活或抑制系统的药物和药物类别。清晰、简洁的插图突出了关键点，药物摘要表提供了快速获取基本信息的途径。
全面更新了所有章节，包括最近批准的药物。
近40个流行和实用的药物汇总表，包含了临床应用、严重和常见不良反应、禁忌症和治疗注意事项等最新信息。
新增一章关于药物转运体的内容，并广泛修订了关于药物与受体相互作用、药效学、药物毒性和药物基因组学的资料。
对第1节：药理学基本原则的主要改动，该节现在为以后所有章节的材料提供了一个全面的框架。
数百幅精心更新的彩色插图，其中包括许多新的或大幅修改的插图，以突出对生理、病理生理和药理机制的新认识。
Highly regarded by both students and instructors, Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 4th Edition, offers an integrated mechanism-based and systems-based approach to contemporary pharmacology and drug development. An easy-to-follow format helps first- and second-year students grasp challenging concepts quickly and efficiently. Each section presents the pharmacology of a physiologic or biochemical system, followed by the pharmacology of a particular aspect of that system; a clinical vignette; a discussion of the biochemistry, physiology, and pathophysiology of the system; and the drugs and drug classes that activate or inhibit the system by interacting with specific molecular and cellular targets. Clear, concise illustrations highlight key points, and drug summary tables offer quick access to essential information.
The Fourth Edition features:
Comprehensive updates to all chapters, including recently approved drugs
Nearly 40 popular and practical Drug Summary Tables with state-of-the-art information on clinical applications, serious and common adverse effects, contraindications, and therapeutic considerations
A new chapter on drug transporters, and extensively revised information on drug-receptor interactions, pharmacodynamics, drug toxicity, and pharmacogenomics
Key changes to Section 1: Fundamental Principles of Pharmacology, which now provides a comprehensive framework for material in all subsequent chapters.[MH1]
Hundreds of meticulously updated and colorized illustrations, including many that are new or substantially modified to highlight new understanding of physiologic, pathophysiologic, and pharmacologic mechanisms
