科研星球

「电子书」Progress in Molecular Biology and Translational Science 分子生物学与转化科学进展 PDF

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G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. They are also responsible for our sensing of exogenous stimuli, including photons and odorants. GPCRs regulate almost every aspect of our physiological functions. It is estimated that 40% to 50% of currently used therapeutic drugs target GPCRs directly or indirectly. Because the current drugs target only a small portion of the GPCRs, opportunities for targeting the remaining GPCRs is enormous. This volume reviews the latest developments in this rapidly advancing field.* This series provides a forum for discussion of new discoveries, approaches.


G蛋白偶联受体(GPCRs)转导来自各种内源性配体的信号,包括离子、氨基酸、核苷酸、脂类、肽类和大糖蛋白激素。它们还负责我们对外源性刺激的感应,包括光子和气味剂。GPCRs几乎调节着我们生理功能的每一个方面。据估计,目前使用的治疗药物中有40%至50%直接或间接地针对GPCRs。由于目前的药物只针对一小部分GPCRs,因此针对其余GPCRs的机会是巨大的。本书回顾了这一快速发展的领域的最新进展。

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