本书着眼于改善人类疾病的诊断、预后和管理，对临床流行病学至关重要的研究设计、测量和评价问题进行了探讨。这本《临床流行病学》第二版。实践与方法》开篇就介绍了如何最好地构思一个临床研究问题，与在人类身上进行研究项目相关的伦理学，以及临床研究中出现的各种偏见的定义。从那里开始，它继续研究与各种研究设计相关的设计、测量和分析问题，包括纵向研究中的风险确定、随机对照临床试验中的治疗评估以及诊断测试的评估，然后深入到更专业的临床遗传研究领域，最后总结了循证决策中使用的基本方法，包括批判性评估、使用荟萃分析汇总多项研究、卫生技术评估、临床实践指南、卫生政策的制定、转化研究、如何利用行政数据库以及知识转化。本书是为非常成功的《分子生物学方法》系列编写的，各章包括了确保现实世界成功的那种细节和实用建议。
综合性和权威性，临床流行病学。临床流行病学：实践与方法，第二版旨在教育研究人员如何进行临床研究，不仅对医疗从业人员有帮助，而且对希望将其工作扩展到人类的基础科学家、对科学评价感兴趣的联合卫生专业人员以及临床流行病学的受训人员都有帮助。
Focusing on improving the diagnosis, prognosis, and management of human disease, this book takes on the issues of research design, measurement, and evaluation which are critical to clinical epidemiology. This second edition of Clinical Epidemiology: Practice and Methods opens with how best to frame a clinical research question, the ethics associated with doing a research project in humans, and the definition of various biases that occur in clinical research. From there, it continues by examining issues of design, measurement, and analysis associated with various research designs, including determination of risk in longitudinal studies, assessment of therapy in randomized controlled clinical trials, and evaluation of diagnostic tests, and then delves into the more specialized area of clinical genetic research, before concluding with basic methods used in evidence-based decision making including critical appraisal, aggregation of multiple studies using meta-analysis, health technology assessment, clinical practice guidelines, development of health policy, translational research, how to utilize administrative databases, and knowledge translation. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and practical advice to ensure real world success.
Comprehensive and authoritative, Clinical Epidemiology: Practice and Methods, Second Edition is intended to educate researchers on how to undertake clinical research and should be helpful not only to medical practitioners but also to basic scientists who want to extend their work to humans, to allied health professionals interested in scientific evaluation, and to trainees in clinical epidemiology.
