科研星球

「电子书」Protein Folding Handbook 蛋白质折叠手册 PDF

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这本独特的手册包含了60多个研究小组的专业知识,涵盖了蛋白质折叠的全部主题--从生物物理学到分子医学。第一部分解释了制约蛋白质稳定性的原理和因素,以及如何利用这些知识来预测折叠途径。它还调查了用于研究蛋白质折叠过程的重要技术,包括光谱、化学和生物技术。第二部分专门讨论细胞背景下的蛋白质折叠、解折叠和错误折叠,介绍了参与蛋白质折叠的伴侣和其他酶,以及淀粉样蛋白和其他疾病状态下错误折叠蛋白质的病理生理学研究。最后讨论了通过基因工程干扰蛋白质折叠过程的可能性,使整个内容更加完善。精心挑选的内容的全面性和出色的质量,使之成为每一位对蛋白质折叠感兴趣的科学家的终极参考。


This unique handbook contains the expertise from more than 60 research groups, covering the entire range of topics in protein folding - from biophysics to molecular medicine. The first part explains the principles and factors governing protein stability, and how this knowledge may be used to predict folding pathways. It also surveys important techniques used to study the protein folding process, including spectroscopic, chemical and biological techniques. The second part is devoted to protein folding, unfolding, and misfolding in the cellular context, introducing chaperones and other enzymes involved in protein folding, as well as a study of the pathophysiology of misfolded proteins in amyloid and other disease states. The whole is rounded off by a discussion of the possibility of interfering with the protein folding process by genetic engineering. The comprehensiveness and outstanding quality of the carefully selected contents make this the ultimate reference for every scientist with an interest in protein folding.

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