科研星球

「电子书」Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Volume 6- Regulation of Autophagy and Selective Autophagy 自噬:

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第6卷介绍了自噬的调节机制;细胞内病原体对自噬机制的利用;自噬在宿主免疫中的作用;以及选择性自噬。注意到对调控的一些机理进展的理解,特别是营养物质供应的重要性;microRNAs;以及与其他蛋白质降解途径的交叉作用。还提供了细胞内病原体对自噬的再利用以获得病原体的益处,其中包括疱疹病毒蛋白对自噬的调控;水痘-带状疱疹病毒与稳态的维持;自噬与乙肝病毒的关系。


阐明了自噬在宿主防御中的意义,对促进抗原呈递;参与胸腺发育;调节节与先天免疫的共享等方面进行了具体阐述。此外,还探讨了线粒体和内吞间隙连接的选择性自噬的降解。


本书对自噬的调控、其在宿主防御和免疫中的作用以及选择性自噬进行了简明扼要的概述,对新手来说是一笔宝贵的财富,同时对更多有经验的科学家和希望更新知识的临床医生来说,本书也是一本很好的参考书。


Volume 6 provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Attention is given to a number of mechanistic advances in the understanding of regulation, particularly the importance of nutrient availability; microRNAs; and cross-talk with other protein degradation pathways. Intracellular pathogen repurposing of autophagy for pathogenic benefit is also provided, with coverage of Herpesvirus protein modulation of autophagy; the varicella-zoster virus and the maintenance of homeostasis; and the relationship between autophagy and the hepatitis b virus.


The significance of autophagy in host defense is elucidated, providing a specific focus on facilitation of antigen presentation; participation in thymic development; and the sharing of regulatory nodes with innate immunity. Selective autophagy for the degradation of mitochondria and endocytosed gap junctions are also explored.


This book is an asset to newcomers as a concise overview of the regulation of autophagy, its role in host defense and immunity, and selective autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge.


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