科研星球

「电子书」Microbiome and Cancer 微生物组与癌症 PDF

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本书涉足一个新的、令人兴奋的发现领域,它将我们目前对癌症的认识与发现与不同类型癌症相关的微生物直接联系起来。最近的研究表明,微生物与癌症的建立有直接的联系,而且它们也能促使癌症的发生以及持续存在。微生物组与癌症》涵盖了目前关于微生物组及其与人类癌症的关系的知识。它为癌症和微生物学领域的新手、高年级本科生、研究生、初级研究人员、住院医师、研究员和已建立的研究人员提供了重要的阅读。我们涵盖了与微生物学中已知的、宽泛的概念相关的领域,以及它们如何与微环境的不断发现以及该微环境中代谢和生理状态的变化相关联,这些变化对于决定该微环境中活动的多微生物内容的不断培育和生存非常重要。


我们涵盖了与胃癌相关的微生物的相互作用,这些微生物对驱动这种特殊的癌症很重要。其他领域包括口腔癌、皮肤癌、卵巢癌、乳腺癌、鼻咽癌、肺癌、间皮瘤、霍奇金和非霍奇金淋巴瘤、多发性胶质母细胞瘤、肝细胞癌,以及与癌症中感染性病原体相关的炎症反应。本书内容包括因感染而发生的代谢变化及其对癌症发展的支持,慢性感染以及检测和控制感染的治疗策略的发展。


微生物组研究领域在过去5年中呈爆炸式增长,我们现在对微生物可能导致人类癌症发病的背景有了越来越多的了解。微生物组研究领域已经证明,人体有特定的组织生物群落,这些生物群落在特定器官部位的变化会导致疾病。这些变化会导致代谢转变的巨大差异,再加上基因突变,将产生完美的利基,从而在该器官部位建立特定的感染程序。我们刚刚开始了解这些变化是什么,以及它们如何影响疾病状态。总的来说,我们希望将主要器官部位的微生物组的不同程度的波动,以及这些变化如何因为失调而影响正常的细胞过程,导致相关组织的增生。


This book ventures into a new and exciting area of discovery that directly ties our current knowledge of cancer to the discovery of microorganisms associated with different types of cancers. Recent studies demonstrate that microorganisms are directly linked to the establishment of cancers and that they can also contribute to the initiation, as well as persistence of, the cancers. Microbiome and Cancer covers the current knowledge of microbiome and its association with human cancers. It provides important reading for novices, senior undergraduates in cancer and microbiology, graduate students, junior investigators, residents, fellows and established investigators in the fields of cancer and microbiology. We cover areas related to known, broad concepts in microbiology and how they can relate to the ongoing discoveries of the micro-environment and the changes in the metabolic and physiologic states in that micro-environment, which are important for the ongoing nurturing and survival of the poly-microbial content that dictates activities in that micro-environment.


We cover the interactions of microorganisms associated with gastric carcinomas, which are important for driving this particular cancer. Additional areas include oral cancers, skin cancers, ovarian cancers, breast cancers, nasopharyngeal cancers, lung cancers, mesotheliomas, Hodgkin’s and non-Hodgkin’s lymphomas, glioblastoma multiforme, hepatocellular carcinomas, as well as the inflammatory response related to the infectious agents in cancers. This book covers the metabolic changes that occur because of infection and their support for development of cancers, chronic infection and development of therapeutic strategies for detection and control of the infection.


The field of microbiome research has exploded over the last five years, and we are now understanding more and more about the context in which microorganisms can contribute to the onset of cancers in humans. The field of microbiome research has demonstrated that the human body has specific biomes for tissues and that changes in these biomes at the specific organ sites can result in disease. These changes can result in dramatic differences in metabolic shifts that, together with genetic mutations, will produce the perfect niche for establishment of the particular infection programmes in that organ site. We are just beginning to understand what those changes are and how they influence the disease state. Overall, we hope to bring together the varying degrees of fluctuations in the microbiome at the major organ sites and how these changes affect the normal cellular processes because of dysregulation, leading to proliferation of the associated tissues.


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