癌症已成为全球第二大流行的健康问题,本质上是细胞信号传导的失灵。了解细胞和组织错综复杂的信号网络是如何让癌症茁壮成长的--以及它们是如何被转化为对抗癌症的有力武器的--是在临床上管理癌症和提高癌症治疗效果的关键。在他们的开创性教科书中,作者提供了一个令人信服的故事,讲述了癌症如何在分子水平上运作,以及使用激酶抑制剂和其他信号通路调节剂的靶向疗法如何遏制并最终治愈癌症。
Cancer, which has become the second-most prevalent health issue globally, is essentially a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow cancer to thrive - and how they can be turned into potent weapons against it - is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors provide a compelling story of how cancer works on the molecular level, and how targeted therapies using kinase inhibitors and other modulators of signaling pathways can contain and eventually cure it.